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. 2024 Feb 29;15:1349601. doi: 10.3389/fimmu.2024.1349601

Figure 6.

Figure 6

NOD.Ifih1R increases B cell activation in non-draining lymph nodes (LN) and decreases the frequency of splenic IL-10+CD138+ cells. (A) Representative gating of plasma cells (CD19+B220-CD138+) from lymph nodes of 14-week-old NOD.Ifih1NR/NR and NOD.Ifih1R/R mice by flow cytometry. (B) The frequency of plasma cells in lymph nodes of 14-week-old mice (n=14 NOD.Ifih1NR/NR , n=18 NOD.Ifih1R/R ). (C) Representative gating of CD80+ B cells (B220+CD80+) from lymph nodes of 14-week-old NOD.Ifih1NR/NR and NOD.Ifih1R/R mice by flow cytometry. (D) The frequency of CD80+ B cells in lymph nodes of 14-week-old mice (n=14 NOD.Ifih1NR/NR , n=18 NOD.Ifih1R/R ). (E) Representative gating of IL-10+ B220-CD138+ cells from spleens of 14-week-old NOD.Ifih1NR/NR and NOD.Ifih1R/R mice by flow cytometry. (F) The frequency of IL-10+ B220-CD138+ cells from spleens of 14-week-old mice (n=5 NOD.Ifih1NR/NR , n=6 NOD.Ifih1R/R ). (G) Representative gating of IL-10+ B220-CD138+ from lymph nodes of 14-week-old NOD.Ifih1NR/NR and NOD.Ifih1R/R mice by flow cytometry. (H) The frequency of IL-10+ B220-CD138+ cells from lymph nodes of 14-week-old mice (n=5 NOD.Ifih1NR/NR , n=6 NOD.Ifih1R/R ). P values were determined using student’s unpaired t tests. All data are mean ± SEM.