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. 2024 Feb 29;15:1349601. doi: 10.3389/fimmu.2024.1349601

Figure 8.

Figure 8

NOD.Ifih1R increases insulitis in 14-week-old males. (A) Representative images of scoring criteria used: 0=no infiltration, 1=peri-insulitis, 2=<25% islet infiltration, 3 = 25-75% islet infiltration, and 4=>75% islet infiltration. Scale bars: 50μM. (B) Representative images showing insulitis from 14-week-old NOD.Ifih1NR/NR and NOD.Ifih1R/R mice. Scale bars: 50μM. (C, D) Insulitis scores from 14-week-old (C) males (n=6 NOD.Ifih1NR/NR , n=5 NOD.Ifih1R/R ) and (D) females (n=5 per genotype). Scores were excluded if less than 10 islets/section could be identified. (E, F) insulitis/islet in 14-week-old (E) males (n=6 NOD.Ifih1NR/NR , n=5 NOD.Ifih1R/R ) and (F) females (n=6 NOD.Ifih1NR/NR , n=7 NOD.Ifih1R/R ). (G, H) mean islets/field in 14-week-old (G) males (n=6 NOD.Ifih1NR/NR , n=5 NOD.Ifih1R/R ) and (H) females (n=6 NOD.Ifih1NR/NR , n=7 NOD.Ifih1R/R ), P values were determined using student’s unpaired t tests. All data are mean ± SEM.