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. 2024 Feb 29;11:1305431. doi: 10.3389/fmed.2024.1305431

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Copyright © 2024 Wang, Zhang, Shen, Wei, Zhao, Xiao, Lv, Qin, Xu, Zhou, Xie, Li and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gouty nephropathy (GN) cell pyroptosis. The formation of inflammasome activates Caspase-1, which cleaves the gasdermin D (GSDMD) protein, activating its N-terminal structural domain, GSDMD-N. GSDMD-N then forms pores in the cell membrane, leading to membrane rupture and the release of IL-1β and IL-18 pro-inflammatory cytokines, inducing cellular pyrolysis. Simultaneously, cytoplasmic lipopolysaccharide (LPS) activates Caspase-4/5/11, which cleaves the GSDMD protein, triggering cellular pyroptosis.