Table 2.
Most common categories of medications associated with adverse drug reactions at admission.
| Categoriesa,b | Medications leading to hospitalizationc (n = 368) | Medications associated with any ADRs (n = 494) |
|---|---|---|
| Cardiovascular agents | 83 (22.6) | 117 (23.7) |
| Antiarrhythmic agents | 14 (3.8) | 16 (3.2) |
| Diuretics | 30 (8.2) | 51 (10.3) |
| Beta-blocking agents | 11 (3.0) | 14 (2.8) |
| RAS inhibitors | 17 (4.6) | 22 (4.5) |
| Musculoskeletal agents | 62 (16.8) | 67 (13.6) |
| NSAIDs | 41 (11.1) | 44 (8.9) |
| COX-2 inhibitors | 21 (5.7) | 22 (4.5) |
| Antithrombic agents | 49 (13.3) | 102 (20.6) |
| Antiplatelet agents | 12 (3.3) | 18 (3.6) |
| Anticoagulant agents | 12 (3.3) | 33 (6.7) |
| Psychotropic agents | 39 (10.6) | 48 (9.7) |
| Benzodiazepines | 23 (6.3) | 26 (5.3) |
| Antipsychotics | 11 (3.0) | 17 (3.4) |
| Antidiabetic agents | 37 (10.1) | 39 (7.9) |
| Sulfonylureas | 15 (4.1) | 15 (3.0) |
| Insulins | 13 (3.5) | 14 (2.8) |
| Psychoanaleptics | 18 (4.9) | 18 (3.6) |
| Antineoplastic agents | 17 (4.6) | 20 (4.0) |
| Antimicrobial agents | 13 (3.5) | 19 (3.8) |
| Herbal medications | 12 (3.3) | 17 (3.4) |
aThese included medications representing more than 3% of all medications.
bThese categories of medications were based on the World Health Organization Anatomical Therapeutic Chemical classification.
cA total of 368 medications resulted in 287 hospitalizations.
ADR adverse drug reaction, COX-2 cyclooxygenase-2, DOAC direct-acting oral anticoagulant, DPP-4 dipeptidyl peptidase IV, NSAIDs nonsteroidal anti-inflammatory drugs, RAS renin-angiotensin system.