Table 2.
Characteristics of ELFN1-AS1 prognostic models
| Tumor type | Data source and sample size | lncRNA type | Signature | Nomogram | Prognostic and diagnostic value (AUC) | Refs. |
|---|---|---|---|---|---|---|
| CC |
TCGA: 39 normal and 379 CC cases FerrDb: 259 genes TIMER and CIBERSORT: 22 immune cells |
Ferroptosis-related |
Prognostic risk score: 15 lncRNAs |
Age, sex, stage, TNM, risk score |
1-, 3-, and 5-year OS in training set: 0.796, 0.828, and 0.866 1-, 3-, and 5-year OS in testing set: 0.668, 0.724, and 0.856 |
[77] |
| CRC |
TCGA: 51 normal and 582 CRC cases FerrDb:382 genes Clinical sample: 30 pairs |
Ferroptosis-related |
Prognostic risk score: 4 lncRNAs |
Age, T, stage, risk score |
1-, 3-, and 5-year OS: 0.736, 0.710, and 0.746 |
[78] |
| CC |
TCGA: 355 COAD cases ICGC:134 COAD cases GDSC: Drug sensitivity |
Ferroptosis-related |
Prognostic risk score: 9 lncRNAs |
Age, stage, risk score |
1-, 3-, and 5-year OS in original set: 0.701, 0.785, 0.821 1-, 3-, and 5-year OS in testing set: 0.701, 0.751, 0.833 Nomogram C-index: 0.801 |
[74] |
| CRC |
TCGA: 51 normal and 644 CRC cases ImmLnc: 2617 genes Clinical sample:10 pairs |
Immune-related |
Prognostic risk score: 7 lncRNAs |
– |
OS in entire set: 0.855 |
[80] |
| OSa |
TCGA: 85 cases Molecular Signature: 331 genes |
Immune-related |
Prognostic risk score: 6 lncRNAs |
– |
5-year OS in train set: 0.937 5-year OS in test set: 0.797 5-year OS in entire set: 0.879 |
[81] |
| CCa |
TCGA: 257 cases Molecular Signatures: 331 genes GDSC: Drug sensitivity |
Immune-related |
Prognostic risk score: 6 lncRNAs |
age, stage, grade, histological type, risk score |
1-, 3-, and 5-year OS in training set: 0.775, 0.748, 0.746 1-, 3-, and 5-year OS in testing set: 0.785, 0.689, 0.681 1-, 3-, and 5-year OS in entire set: 0.812, 0.635, 0.603 |
[76] |
| DLBCL |
GEO: 709 cases TMUCIH: 160 cases GeneCards: 2025 genes |
Epigenetic-related |
Prognostic risk score: 9 lncRNAs |
Age, LDH, ECOG, GCB vs. non-GCB, extranodal sites, risk score |
1-, 3-, and 5-year OS in training set: 0.765, 0.780, 0.760 1-, 3-, and 5-year OS in testing set1: 0.597, 0.598, .615 1-, 3-, and 5-year OS in training set2: 0.686, 0.753, 0.760 |
[82] |
| CC |
TCGA: 452 patients GEO: 177 patients |
N7-Methylguanosine-related |
Prognostic risk score: 8 lncRNAs |
Age, TNM, risk score |
1-, 3-, and 5-year OS in training set: 0.671, 0717, 0.692 1-, 3-, and 5-year OS in testing set: 0.679, 0.617, 0.648 |
[83] |
| ECa |
TCGA: 208 normal and 35 ECa cases 96 genes DrugBank: Drug data |
DNA methylation-related |
Prognostic risk score: 2 lncRNAs |
– |
1-, 3-, and 5-year OS in training set: 0.690, 0.590, 0.630 1-, 3-, and 5-year OS in testing set: 0.690, 0.590, 0.630 1-, 3-, and 5-year OS in entire set: 0.730, 0.660, 0.67 |
[84] |
| CRC |
TCGA: 387 CRC cases GEO: 546 cases GeneCards: 133 genes |
Pyroptosis-related |
Prognostic risk score: 4 lncRNAs |
– |
1-, 3-, and 5-year OS in training set: 0.700, 0.698, 0.674 1-, 3-, and 5-year OS in testing set: 0.648, 0.608, 0.601 |
[85] |
| HCC |
TCGA: 374 HCC and 50 normal cases HADb: 232 genes |
Autophagy-related |
Prognostic risk score: 7 lncRNAs |
TNM, risk score |
1-, and 3-year OS in entire set: 0.785, 0.710 |
[87] |
AUC area under curve, CC colon cancer, CCa cervical cancer, CIN colonic intraepithelial neoplasia, COAD colon adenocarcinoma, CRC colorectal cancer, DLBCL diffuse large B-cell lymphoma, ECa endometrial cancer, ECOF Eastern Cooperative Oncology Group, GCB germinal center B-cell-like, GDSC Genomics of Drug Sensitivity in Cancer, HADb human autophagy database, HCC hepatocellular carcinoma, LDH lactate dehydrogenase, OS overall survival, OSa osteosarcoma, TCGA The Cancer Genome Atlas