Fig. 4.

Pedigrees of large HAE families with specific causal variant in SERPING1 gene

HAE-affected family members carrying the causal variant are shown in black and healthy individuals are depicted by a blank symbol. Deceased family members are shown with a sloping line through the symbol. Divorce is shown as horizontal line connecting 2 symbols with 2 diagonal hash marks. Individuals with only clinical symptoms indicating HAE who were not genetically tested are marked by asterisk (∗). Variant c.1220del was found in 2 large families which are divided and marked as 1) and 2).