Table 3.

Univariate and multivariate analysis of DFS and OS on potential risk factors among 74 stage III NSCLC patients.

	Univariate		Multivariate
	HR (95% CI)	P value	HR (95% CI)	P value
DFS variables†
Age (< 60/ ≥ 60)	2.01 (1.18–3.42)	0.01*	1.93 (1.04–3.57)	0.04*
Gender (Male/ female)	1.21 (0.68–2.14)	0.52
ECOG PS (≥ 2/ 0–1)	1.18 (0.54–2.61)	0.68	1.17 (0.51–2.70)	0.71
Smoking (never/ current-former)	1.27 (0.74–2.20)	0.39	1.10 (0.62–1.95)	0.76
Histology (Non-SQ/ SQ)	1.24 (0.69–2.22)	0.47
T stage (T3-4/ T1-2)	0.78 (0.44–1.37)	0.38
N stage (N2-3/ N0-1)	1.45 (0.74–2.87)	0.28
Stage (IIIB/IIIA)	1.43 (0.87–2.34)	0.16	1.30 (0.76–2.21)	0.34
Chemotherapy (no/ yes)	1.51 (0.60–3.82)	0.38
Radiation dose (≤ 60/ > 60)	1.38 (0.19–10.23)	0.75
LKB1 expression (< cutoff/ ≥ cutoff)	1.97 (1.10–3.51)	0.006*	2.15 (1.21–3.80)	0.009*
OS variables†
Age (< 60/ ≥ 60)	1.98 (1.09–3.59)	0.02*	1.73 (0.88–3.43)	0.11
Gender (Male/ female)	0.89 (0.46–1.72)	0.73
ECOG PS (≥ 2/ 0–1)	1.24 (0.49–3.14)	0.65	1.20 (0.44–3.28)	0.72
Smoking (never/ current-former)	1.27 (0.68–2.34)	0.46	1.16 (0.59–2.30)	0.67
Histology (Non-SQ/ SQ)	1.15 (0.61–2.16)	0.67
T stage (T3-4/ T1-2)	1.11 (0.58–2.13)	0.75
N stage (N2-3/ N0-1)	1.68 (0.75–3.73)	0.21
Stage (IIIB/IIIA)	1.84 (1.05–3.25)	0.04*	1.85 (1.02–3.35)	0.04*
Chemotherapy (no/ yes)	2.00 (0.79–5.10)	0.15
Radiation dose (≤ 60/ > 60)	3.81 (0.49–29.51)	0.20
LKB1 expression (< cutoff/ ≥ cutoff)	1.90 (1.00–3.62)	0.02*	2.03 (1.05–3.92)	0.04*

^†Category after the slash (/) was set as reference category. CI: confidence interval, DFS: disease free survival, ECOG PS: Eastern Cooperative Oncology Group performance status, HR: hazard ratio, OS: overall survival, SQ: squamous cell carcinoma.

Significant values are in [bold].