Figure 2.

Relationship of years before/after the final menstrual period (FMP) with carotid artery intima-media thickness (CIMT). Estimates are from a linear model (dashed line) or a piece-wise linear mixed-effects model (solid line) with 3 time segments: pretransition (>2 years before FMP), menopausal transition (2 years before to 2 years after FMP), and posttransition (>2 years after FMP). The linear model included a term for years before/after the FMP, while the piece-wise model included terms for years before/after the FMP, and the interaction of the second time segment (>2 years before FMP) and the third time segment (>2 years after FMP) with years before/after FMP. All models included a random intercept per participant and were adjusted for age at FMP, HIV status, study site, race/ethnicity, income, educational attainment, employment, smoking status, alcohol use status, substance use, hepatitis C virus serostatus, hormonal contraceptive use, body mass index, systolic and diastolic blood pressure, diabetes, use of lipid-lowering medications, and use of hypertension medications. Among participants with HIV, model additionally adjusted for HIV viral load, CD4⁺ cell count, and antiretroviral therapy. Sample sizes (number of women/person-visits): all (284/977), women with HIV (209/705), women without HIV (75/272).