Figure 4.
The combination of soluble glycoprotein 120 (sgp120) levels and anti–cluster A antibodies correlates positively with subclinical cardiovascular disease. Associations are displayed between the size of coronary artery plaque volume and sgp120 levels (A), anti–cluster A antibodies (B), and the multiplicative combination of both (C) in people living with human immunodeficiency virus who are positive for sgp120 and have detectable subclinical cardiovascular disease. Values for sgp120, anti–cluster A antibodies, and total plaque volume (mm3) were log2 transformed. Univariable and multivariable linear regressions were performed, with the beta parameters representing the mean predicted change in log total plaque volume for each 1-log2 increase in the exposure. Multivariable models are adjusted for age, sex, smoking status, low- or high-density lipoproteins, diabetes mellitus, hypertension, alcohol use disorder, intravenous drug use, and duration of antiretroviral therapy. Abbreviations: CI, confidence interval; RU, relative units.