FIGURE 1.

MRI findings in classic and remitting MLC patients. (A–D) MRI from an 11-year-old patient depicting an example of classic MLC. Anterior temporal and frontal subcortical cysts are visible in the sagittal T1-weighted MRIs in panels A and B (arrowheads). T2-weighted images in panel C and D show diffuse hyper intensity and swelling of the cerebral white matter with broadening of gyri (compare width of gyri in C and D to K and L). (E–H) MRI in a 9-month-old MLC patient and (I–L) images of the same patient at 7 years, showing the remitting phenotype. The anterior temporal cyst visible in panel E at 9 months (arrowhead) is no longer visible in panel I at 7 years. (F, J) No frontal subcortical cysts are present. Panels G, H, K, and L show that the cerebral white matter is initially T2-hyperintense and slightly swollen and that this T2-hyperintensity and swelling disappear over the years.