FIGURE 5.

MRI findings in a Jacobsen syndrome patient. (A–D) MRIs from a 3-year-old Jacobsen syndrome patient with a chromosomal deletion that includes GLIALCAM. Numerous anterior temporal and frontal subcortical cysts are visible in the sagittal T1-weighted MRIs in panels A and B (arrowheads). T2-weighted images in (C and D) reveal extensive signal abnormality and swelling of the cerebral white matter. (E–H) Follow-up of the same patient at 10 years of age. Subcortical cysts persist [arrowheads in (E,F)], but there is clear improvement in signal abnormality and swelling of the cerebral white matter.