Table II.

Clinicopathological characteristics of cases of pleomorphic infiltrative lobular carcinomas (PILC) of the male breast previously described in the literature, and of the present case.

	Maly et al.	Rohini et al.	Ishida et al.	Zahir et al.	Murzabdillaeva et al. first case	Murzabdillaeva et al. second case	Saggini et al.	Costa et al.	Present case
Year of report	2005	2010	2013	2013	2017	2017	2020	2022	2023
Age	44	55	76	68	63	79	80	73	46
Presentation	2.5 cm mass	4 cm mass	3 cm mass	2.8 cm mass	Left neck mass, 1.7 cm breast mass with nipple retraction and skin rash	2 cm mass and skin itchiness	3 cm erythematous plaque of the nipple	3.9 cm mass, nipple retraction and skin thickening	4 cm mass
Genetic mutations	Not evaluated	Not evaluated	Not evaluated	Not evaluated	Not evaluated	Negative for genetic testing	Not evaluated	BRCA2 mutation	PALB2 germline mutation c.1240C>T p.(Arg414*)
Risk factor	Grandmothers died of breast cancer	No risk factors	Gynecomastia Progestational agent for prostatic carcinoma for 10 years	Gynecomastia, alcohol abuse	Gynecomastia	No risk factors	Not reported	Obesity, treatment with finasteride for benign prostatic hyperplasia, family history of breast cancer (two nieces)	Mother with breast cancer
Estrogen Receptor	Positive	Not evaluated	Positive	Positive	Negative	Positive	Positive	Positive	Positive
Progesterone Receptor	Positive	Not evaluated	Negative	Positive	Negative	Positive	Positive	Positive	Positive
Her2/neu	Negative	Not evaluated	Negative	Negative	Negative	Negative	Negative	Negative	Negative and not amplified
E-Cadherin	Negative	Negative	Negative	Negative	Negative	Negative	Negative	Negative	Negative
Lymph node involvement	None	None	None	pN2a	pN3c	None	Not reported	pN1(sn)	pN0(i+)(sn)
Treatment	Radical mastectomy with axillary dissection	Radical mastectomy with axillary dissection	Not reported	4 cycles of chemotherapy	7 cycles of chemotherapy, radiotherapy	Left simple mastectomy with sentinel lymph node biopsy	Not reported	Left simple mastectomy with nipple excision and sentinel lymph node biopsy, chemotherapy, radiotherapy	Left simple mastectomy with sentinel lymph node biopsy, chemotherapy and radiotherapy
Follow-up	Disease free at 2 years	Disease free at 1 year	Disease free at 2 months	Disease free at 3.5 months	Brain metastasis	Disease free	Not reported	Not reported	Disease free at 1 year