Table I.
Clinical and pathological characteristics of the reviewed cohort.
| Reference | Age | Sex | Smoking history (Y/N) | Neoplasm diameter (cm) | Neoplasm localization | Metastasis localization | Therapy | Follow-up (months) |
|---|---|---|---|---|---|---|---|---|
| Pelosi, 2015 5 | 77 | M | Y | 8,5 | Left (hilar) | Pleural effusion | None | DOD (1) |
| Hayashi, 2018 8 | 73 | M | Y | 1,9 | LUL | No | Surgery | NA |
| Spinelli, 2019 9 | 51 | M | Y | 3,1 | RUL | Brain, adrenal gland, mediastinal LN | RT+CT | DOD (3) |
| Pelosi, 2021 15 | 62 | F | Y | 4,5 | Right | Brain, intralung, mediastinal LN | CT+gefitinb | DOD (48) |
| 62 | M | Y | 4,7 | LLL | Mediastinal LN, liver | CT+pembrolizumab | DOD (3) | |
| Li Hui, 2021 10 | 54 | F | N | NA | LUL | Brain, bone, mediastinal LN | CT+pemetrexed | AWD (NA) |
| Chen Bing, 2022 11 | 58 | F | NA | 2,2 | LUL | NA | NA | NA |
| Yang, 2022 7 | 58 | M | Y | 1,9 | LUL | No | Surgery, CAR-NK cell therapy | AWD (9) |
| Cai, 2022 12 | 38 | M | N | 4,5 | Right (mediastinum) | Bilateral intralung, bone, mediastinal LN | Carboplatin and pemetrexed | NA |
| Savari, 2022 13 | 26 | F | N | 5,2 | LLL, central | No | Surgery | AWD (17) |
| Savari, 202314 | 77 | M | Y | 4,4 | Peripheral | Brain, liver | NA | DOD (10,5) |
| 68 | F | Y | 4,2 | Peripheral | Brain | NA | AWD (55) | |
| 84 | F | NA | 2,3 | NA | No | Surgery | NA | |
| 80 | M | Y | 6,4 | Central | NA | NA | DOC (22,6) | |
| 67 | F | NA | 0,6 | Peripheral | No | Surgery | NA | |
| 90 | F | Y | 3 | Peripheral | Intralung, supraclavicular LN | Surgery | DOD (51,3) | |
| 69 | M | Y | 2,2 | Peripheral | Liver, adrenal gland, bone, pancreas, stomach | NA | DOD (11,8) | |
| 65 | M | Y | 3,4 | Peripheral | No | NA | AWD (34,5) | |
| 79 | F | NA | NA | NA | NA | NA | NA | |
| 86 | M | NA | 2,2 | NA | NA | NA | NA | |
| 73 | F | NA | 5,2 | NA | NA | NA | NA | |
| 79 | M | Y | 1,3 | Central | No | Surgery | NA | |
| 74 | M | Y | 1,3 | Peripheral | Mediastinal LN, pleura | NA | AWD (1,3) | |
| 94 | F | N | 1,9 | Peripheral | No | RT | AWD (12) | |
| Present case | 64 | F | Y | 5 | RUL | Mediastinal LN, bone, adrenal gland, liver, brain | RT | DOD (3) |
| AWD alive with disease, CT chemotherapy, DOC dead of other causes, DOD dead of disease, LLL left lower lobe, LN lymph nodes, LUL left upper lobe, RUL right upper lobe, NA not available. | ||||||||