Effects of Si-UCNPs or AzSi-UCNPs on the abundance of protein biomarkers. Results are summarized for 24 hours UCNP treatments. The changes in protein levels relative to the vehicle controls are depicted. ↔, no or minor change, abundance ≤ 20% reduced or increased compared to control; ↓, reduction to 60–79%; ↓↓, reduction to less than 60%; ↑, increase to 121–140%; ↑↑, increase to more than 140%.

Protein abundance
Protein	NIH3T3 cells		LLC-PK1 cells
	Si-UCNPs	AzSi-UCNPs	Si-UCNPs	AzSi-UCNPs
Lamin A	↔	↓↓	↔	↔
Lamin B	↔	↓	↔	↓↓
α-Tubulin	↔	↔	↔	↑
Nrf2	↓	↔	↔	↔
NFκB	↔	↔	↔	↔
GAPDH	↓	↔	↔	↔
p53	↔	↔	↑	↔
RPA194	↓	↔	↔	↔
Fibrillarin	↔	↔	↔	↔
Nucleolin	↓	↓	↑↑	↑
p/t-eIF2α	↑	↑↑	↔	↔
Grp78	↔	↑	↔	↑
Grp94	↑	↑	↔	↔
CHOP	Not induced	Not induced	Not induced	Not induced
Hsp70	↑	↑↑	↔	↑
Hsp90	↔	↔	↑↑	↑↑
VCP	↔	↔	↔	↔