Table 2.

Significant results of sensitivity analysis.

Exposure	Outcome	Source	GWAS ID	MR Egger intercept test	MR-PRESSO Global test	Cochran’s Q-test	R 2	F-value
Forward MR analysis
Genus Parabacteroides	General pain	MC	ukb-d-2956	0.513	0.855	0.787	0.019	32.88
Class Bacteroidia	Back pain	DMP	ukb-a-346	0.549	0.445	0.415	0.037	23.08
Order Bacteroidales	Back pain	DMP	ukb-a-346	0.549	0.446	0.415	0.037	23.08
Phylum bacteroidetes	Back pain	DMP	ukb-a-346	0.551	0.445	0.415	0.037	23.07
Class Bacteroidia	Back pain	DMP	ukb-b-8463	0.236	0.584	0.540	0.037	23.08
Order Bacteroidales	Back pain	DMP	ukb-b-8463	0.236	0.584	0.540	0.037	23.08
Phylum bacteroidetes	Back pain	DMP	ukb-b-8463	0.236	0.584	0.539	0.037	23.07
Reverse MR analysis
Knee pain	Genus Howardella	MC	ukb-a-353	0.798	0.649	0.552	0.002	22.77
Knee pain	Order Coriobacteriales	DMP	ukb-a-353	0.450	0.405	0.331	0.002	22.98

MR, Mendelian randomization; MC, MiBioGen Consortium; DMP, Dutch Microbiome Project.