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. 2024 Mar 14;16:60. doi: 10.1186/s13195-024-01425-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Comprehensive workflow of the study. a Data collection from three centers: ADNI, Xuanwu Hospital, and Tongji Hospital. b fMRI preprocessing flow. c Graph representation construction based on fMRI. d Architecture of the STGC-GCAM model. e Visualization of imaging biomarkers using BrainNet Viewer. f Correlation analysis between topological features of disease-related brain regions and clinical indicators. g Survival analysis of MCI patients using imaging markers. h Investigation of the mediating effects of brain region topology characteristics on cognitive disorders caused by Aβ, tau, and neural variants