Table 1.
Demographic and clinical characteristics of included multi-site participants
| Cohort | ADNI | Xuanwu | Tongji | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Site | site1 | site2 | site3 | site4 | site5 | site6 | ||||||||||||
| Group | CN n = 139 | MCI n = 244 | AD n = 132 | CN n = 440 | MCI n = 232 | AD n = 90 | CN n = 148 | MCI n = 121 | AD n = 38 | CN n = 241 | MCI n = 46 | AD n = 18 | CN n = 71 | MCI n = 85 | AD n = 57 | CN n = 66 | MCI n = 62 | AD n = 42 |
| Gender (M/F) |
58 /81 |
138 /106a |
69 /63 |
176 /264 | 127 /105a |
58 /32b |
71 /77 |
50 /71a |
15 /23b |
101 /140 |
22 /24 |
7 /11 |
40 /31 |
38 /47 |
36 /21b |
31 /35 |
28 /34 |
19 /23 |
|
Age (mean ± SD) |
75.4 ± 6.1 | 73.0 ± 8.1 | 74.5 ± 7.2 | 71.0 ± 6.3 | 76.0 ± 8.3a | 77.4 ± 7.9b | 64.0 ± 12.5 | 69.0 ± 9.8a | 73.0 ± 8.8b | 66.2 ± 5.2 | 68.3 ± 9.6a | 70.4 ± 11.3b | 71.0 ± 8.0 | 71.6 ± 8.1 | 73.7 ± 8.3 | 68.0 ± 6.7 | 73.1 ± 6.1a | 74.4 ± 8.8b |
|
Edu (mean ± SD) |
16.7 ± 2.1 | 16.1 ± 2.6a | 15.6 ± 2.8b | 16.3 ± 2.1 | 15.7 ± 2.8a | 15.6 ± 2.6b | 12.0 ± 8.3 | 10.0 ± 4.5a | 9.0 ± 5.0b | 12.4 ± 3.2 | 11.5 ± 4.2 | 13.8 ± 2.9 | 12.0 ± 3.7 | 10.9 ± 4.3a | 8.3 ± 5.4b | 12.4 ± 3.4 | 9.0 ± 4.0a | 8.7 ± 5.3b |
|
sMCI /pMCI (conversion time) |
- | 164/80 (21.0 ± 12.0) | - | - | 214/17 (21.4 ± 6.3) | - | - | 63/58 (22.0 ± 15.0) | - | - | 35/11 (17.3 ± 4.3) | - | - | - | - | - | - | - |
|
APOEε4 (-/ +) |
83 /56 |
147 /97a |
16 /116b |
261 /142 |
136 /78 |
36 /44b |
67 /28 |
51 /57a |
18 /13 |
193 /47 |
25 /19a |
8 /9b |
- | - | - | - | - | - |
|
Aβ (-/ +) |
31 /13 |
34/ 42a |
4/ 39b |
191 /60 |
57 /32a |
7 /40b |
23 /0 |
0 /1 |
0 /4 |
70 /13 |
4 /5 |
2 /2 |
- | - | - | - | - | - |
|
MMSE (mean ± SD) |
29.0 ± 1.4 | 27.8 ± 2.0a | 22.0 ± 3.6b | 28.9 ± 1.6 | 27.6 ± 2.0a | 21.4 ± 4.2b | 28.0 ± 2.1 | 24.0 ± 3.6a | 18.0 ± 3.8b | 28.8 ± 1.3 | 25.6 ± 2.9a | 16.8 ± 71b | 27.0 ± 2.2 | 23.8 ± 3.3a | 14.7 ± 6.2b | 27.2 ± 2.1 | 23.9 ± 2.8a | 15.1 ± 5.3b |
| CDR-SB (mean ± SD) | 0.1 ± 0.2 | 1.5 ± 1.1a | 4.9 ± 1.9b | 0.08 ± 0.3 | 1.5 ± 1.1a | 6.0 ± 3.0b | - | - | - | - | - | - | - | - | - | - | - | - |
Age, Education, and MMSE data were given as mean standard ± SD. a p < 0.05, comparison between CN and MCI. b p < 0.05, comparison between CN and AD. Abbreviations: CDR-SB The sum of boxes of clinical dementia rating scale, CN Cognitively normal, Edu Education, MMSE Mini-Mental State Examination, MCI Mild cognitive impairment, SD Standard deviation, pMCI Progressive MCI, sMCI Stable MCI