Table 1.

Summary of key findings in the literature

Topic of interest	Key findings
Abdominal pain	• Abdominal pain is a frequently reported symptom (e.g., reported by 84% of patients in 1 study)
GI symptoms	• Most commonly reported GI symptoms are bloating (64%), flatulence (33%), bowel movement/stool symptoms (e.g., diarrhea [75%], change in stool color [51%], fatty stools [49%], constipation [48%], bowel urgency [33%]), and dietary symptoms (e.g., weight loss [67%], loss of appetite [33%]) • Steatorrhea can only generally be reduced by 60–70% using PERT
HRQoL	• Severity of abdominal pain, chronic pancreatic diarrhea, low body weight, and loss of work independently contributed to the physical component score of the Short Form-36 (adjusted R2 = 33.8%)
Emotional functioning	• No articles related to emotional functioning related to EPI were located
Comorbidities	• Most common comorbidities included diabetes, pancreatic resections and other pancreatic interventions, severe/acute pancreatitis, chronic pancreatitis, and other GI disorders
PERT	• Commonly used efficacy endpoints included coefficient of fat absorption, body weight, HRQoL measures, and clinical symptoms

Abbreviations EPI, exocrine pancreatic insufficiency; GI, gastrointestinal; HRQoL, health-related quality of life; PERT, pancreatic enzyme replacement therapy