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. 2024 Mar 14;22:278. doi: 10.1186/s12967-024-05070-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — The antitumor activity in vivo. A Schematic illustrating the CLPs-miR treatment assays. THP-1 cells were implanted subcutaneously into BALB/c-nu mice (B) Growth record curves of subcutaneous tumors in nude mice during the experiment. C Representative photographs of subcutaneous tumors were harvested from all treatment groups. D Tumors harvested from nude mice were weighed. E, G The subcutaneous tumors of mice in all groups were removed and ground, and then western blot assays were used to detect the expression of the listed proteins. (H) Immunohistochemical analysis of Ki67, NRF2, HO-1, and SOD2. Scare bar: 100 µm. (n = 4; mean ± SD; One-way ANOVA), *P < 0.05, **P < 0.01, ***P < 0.001, ns: no significance, vs. control miRNA (miR-NC) and PBS

Fig. 8 — The antitumor activity in vivo. A Schematic illustrating the CLPs-miR treatment assays. THP-1 cells were implanted subcutaneously into BALB/c-nu mice (B) Growth record curves of subcutaneous tumors in nude mice during the experiment. C Representative photographs of subcutaneous tumors were harvested from all treatment groups. D Tumors harvested from nude mice were weighed. E, G The subcutaneous tumors of mice in all groups were removed and ground, and then western blot assays were used to detect the expression of the listed proteins. (H) Immunohistochemical analysis of Ki67, NRF2, HO-1, and SOD2. Scare bar: 100 µm. (n = 4; mean ± SD; One-way ANOVA), *P < 0.05, **P < 0.01, ***P < 0.001, ns: no significance, vs. control miRNA (miR-NC) and PBS