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Distinct macrophage subsets in the central nervous system. Parenchyma: microglia; Brain-circulation interface: macrophages located in the meninges, choroid plexus, and perivascular spaces; Migrated from blood: monocytes that migrate into the brain from a dysregulated brain–blood barrier and differentiate into macrophages. BAMs border-associated macrophages, CSF cerebrospinal fluid, MФ macrophages
