Table 2.
Between-group differences and regional variation in AT expression of genes involved in adipogenesis and lipid metabolism, in lower vs. upper tertile of A/L ratio
| Low A/L ratio | High A/L ratio | |||||
|---|---|---|---|---|---|---|
| SCABD | OME | p-value | SCABD | OME | p-value | |
| C/EBP-α | 294 ± 101 | 171 ± 119 | 0.007 | 254 ± 127 | 151 ± 80 | 0.010 |
| C/EBP-β | 47 ± 21 | 49 ± 32 | 0.707 | 42 ± 18 | 49 ± 30 | 0.359 |
| C/EBP-δ | 55 ± 30 | 65 ± 50 | 0.523 | 64 ± 32 | 86 ± 64 | 0.244 |
| PPAR-γ2 | 57 ± 16 | 40 ± 19 | 0.008 | 63 ± 43 | 39 ± 21 | 0.037 |
| SREBP-1c | 80 ± 28 | 47 ± 18 | 0,003 | 71 ± 43 | 52 ± 25 | 0.104 |
| β2-AR | 134 ± 47 | 82 ± 24 | 0.012 | 163 ± 71 | 96 ± 34 | 0.011 |
| HSL | 196 ± 58 | 90 ± 39 | ˂0.001 | 207 ± 75 | 100 ± 39 | ˂0.001 |
| FABP4 | 379 ± 132 | 186 ± 95 | ˂0.001 | 445 ± 196 | 216 ± 86 | ˂0.001 |
| LPL | 114 ± 39 | 65 ± 23 | 0.017 | 106 ± 47 | 63 ± 22 | 0.041 |
| GLUT4 | 29 ± 7 # | 23 ± 11* | 0.507 | 41 ± 12 # | 39 ± 15* | 0.884 |
Data expressed as arbitrary units are means ± SD. OME, omental; SCABD, subcutaneous abdominal. For other abbreviations, see legends to Table S1. Quantification of 18 S rRNA was used as a normalization factor. Between-group differences within a tissue in bold at #0.05 < p < 0.1, and *p˂0.05; p values for regional variation in women with low and high A/L ratio are indicated in the corresponding columns