FIG. 14.

Systematic evaluation of the dependence of the Derrida coefficient $\delta$ on the update scheme and on source node perturbations. The ensemble of Cell Collective models shows a general agreement between the Derrida coefficients obtained for synchronous and asynchronous update (top panels). When source nodes not candidates for perturbation, the Derrida coefficient dramatically decreases (bottom panels). For example, note that three cancer drug models (plus signs) lie far from the diagonal in the lower two panels, indicating that these models are highly affected by perturbations to source nodes. This is to be expected, as the source nodes in these models represent known cancer drugs that were selected because they have a tremendous impact on the behavior of cancer cells.