Table II. —Example of causal question related to rehabilitation using Population, Intervention, Comparison, Outcome and Time (PICOT) framework.

PICOT Component	Example
Population	Older adults (aged ≥65 years) with a diagnosis of stroke
Intervention	Dedicated units for inpatient stroke rehabilitation (units with geographically distinct, stroke-dedicated beds and dedicated therapists)22
Comparison	Non-dedicated units for inpatient stroke rehabilitation
Outcome	Risk of fracture
Time (of follow-up)	2 years after baseline (i.e., after index date of stroke)