Table 1. Characteristics of pregnancy-associated breast cancer (PABC) and control breast cancer patients (not pregnant).
| Characteristics | PABC group (n = 87)* |
Control group (n = 252) |
P |
|---|---|---|---|
| Age (years) | |||
| Median value (25th - 75th percentile) | 35.0 (31 - 39) | 36.0 (32 - 39) | |
| Mean value ± standard error | 34.9 ± 4.89 | 35.5 ± 4.83 | |
| Tumor histology (% of cases) | |||
| Ductal/lobular | 79 (90.8) | 232 (92.1) | 0.713† |
| Other | 8 (9.2) | 20 (7.9) | |
| Grade of malignancy (% of cases) | |||
| 1 and 2 | 20 (23.0) | 61 (24.2) | 0.375† |
| 3 | 22 (25.3) | 81 (32.1) | |
| Unknown | 45 (51.7) | 110 (43.7 | |
| Primary tumor size (% of cases) | |||
| T1 + T2 | 25 (28.7) | 97 (38.8) | 0.029† |
| T3 + T4 | 61 (70.1) | 138 (55.4) | |
| Unknown | 1 (1.10) | 14 (5.80) | |
| Axillary lymph node involvement (% of cases) | |||
| Negative | 9 (10.3) | 161 (63.9) | < 0.0001† |
| Positive | 78 (89.7) | 91 (36.1) | |
| Distant metastasis (% of cases) | |||
| Negative | 57 (65.5) | 202 (80.2) | 0.007† |
| Positive | 29 (33.3) | 49 (19.4) | |
| Hormone receptor status (% of cases) | |||
| Negative | 12 (13.8) | 39 (15.5) | 0.226† |
| Positive | 39 (44.8) | 87 (34.5) | |
| Not determined | 36 (41.4) | 126 (50.0) | |
| Interval between first symptoms and diagnosis (% of cases) | |||
| ≤ 6 months | 32 (36.8) | 129 (51.2) | 0.009† |
| > 6 months | 55 (63.2) | 114 (45.2) | |
| Interval between diagnosis and first treatment (days) | |||
| Mean value ± standard error | 79.20 ± 377 | 51.61 ± 109 | 0.402‡ |
| Median value | 22.0 | 28.5 | |
*
Excludes six PABC patients with no matching controls;
†
Values based on χ2 test;
‡
Value based on Mann-Whitney test. Staging and grade of malignancy according to the TNM system.