Table 2. Distribution of serum folate, plasma homocysteine (Hcy) and plasma methylmalonic acid (MMA) concentrations according to genotypes of the 19-bp deletion polymorphism in intron-1 of the dihydrofolate reductase (DHFR) gene, in the case and control groups of mothers.
| Concentration | ins/ins | ins/del | del/del | P |
|---|---|---|---|---|
| Case group | ||||
| Folate (ng/ml) | 14.10 | 11.85 | 12.30 | 0.57 |
| Hcy (µmol/l) | 6.21 | 7.25 | 5.34 | 0.20 |
| MMA (µmol/l) | 0.18 | 0.17 | 0.17 | 0.41 |
| Control group | ||||
| Folate (ng/ml) | 15.60 | 14.10 | 14.60 | 0.74 |
| Hcy (µmol/l) | 8.85 | 8.15 | 8.19 | 0.29 |
| MMA (µmol/l) | 0.15 | 0.14 | 0.14 | 0.98 |