Table 2:
Summary Statistics and Sample Size Estimates for Change Baseline to Year Three
| Mean Change (SD) | MSDR* | Sample Size** | |
|---|---|---|---|
| PACC3 components | |||
| MMSE | −1.81 (3.40) | −0.53 | 222 |
| DSST | −4.03 (8.99) | −0.45 | 314 |
| LM-IIA | −0.30 (4.03) | −0.07 | 11390 |
| PACC3 composite scales | |||
| PACC weighting | −1.20 (2.38) | −0.51 | 246 |
| Optimal weighting | −1.84 (3.08) | −0.60 | 177 |
| Simple sum weighting | −6.14 (12.67) | −0.48 | 268 |
*
MSDR = mean to standard deviation ratio
**
Sample size per arm required to detect a 50% slowing of decline under treatment with 80% power.