Table 3.

Reports of radiofrequency treatment of wounds

Author Publication Year	Evidence	Study Design (Sample Size)	Condition	Intervention	Number of Treatments/Intervals	Outcome Measures	Clinical Outcomes	Patient Reported Outcomes	Adverse events
Conner-Kerr and Isenberg et al. 2012 (16)	4	Case series (n = 89)	Chronic pressure ulcers (majority on sacrum and ischium)	Pulsed RF Energy (PRFE)	30-minute treatments BID x 4 weeks	Percent wound surface area reduction (PWAR) Wound healing	PWAR: 51% median reduction (p<0.0001) Wound healing: Baseline median size 9.8cm2 At 4 weeks median size 4.5cm2	Not reported	Not reported
Frykberg et al. 2011 (17)	5	Case report (n = 1)	Transmetatarsal amputation wound due to necrotizing fasciitis	RRFE w/ negative pressure and dermal replacement	BID x 14 weeks	Wound healing	Wound healing: Complete closure at 39 weeks	Not reported	Fixed equinus deformity
Larsen et al. 2008 (18)	4	Case series (n = 2)	Case 1: 1.75cm2 diabetic foot ulcer Case 2: 7cm2 transmetatarsal amputation dehiscence	RRFE w/ Case 1: splint, cane, debridement, silver dressings, petroleum jelly Case 2: silver dressings, debridement, and rook boot.	Not reported	Wound healing	Wound healing: Case 1 and 2 complete closure at 16 weeks; closed at 9 and 7 month follow up, respectively	Not reported	Not reported
Maier et al. 2011 (5)	4	Case series (n = 2)	Case 1: Lower extremity ulcers due to thromboses Case 2: Lower extremity ulcer due to scleroderma	RRFE placed over compression wrapping	30-minute treatments BID x 2 weeks	Pain level Wound healing	Pain level: Both able to tolerate compression dressings again Wound healing: Case 1 complete closure in 3–4 weeks Case 2 80% closure in 11 weeks	Immediate pain reduction	Not reported