FIG. 1.

Protection against lethal MCMV infection by RV7 vaccination. Mice were mock vaccinated (A) or vaccinated with 2 × 10⁵ PFU of RV7 s.c. (B) on days 0 and 14 of the experiment and then challenged with sgMCMV i.p. at the indicated doses on day 28 of the experiment. The indicated number of mice were observed for mortality over the next 21 days. Data were pooled from two experiments, and the percent survival for each challenge dose is graphed versus time. Symbols that match between panel A and panel B correspond to matching challenge doses. Additional data from the experiments are not plotted. RV7-vaccinated mice challenged with 10⁴ PFU of sgMCMV (n = 5) and 2.5 × 10⁴ PFU of sgMCMV (n = 5) all survived.