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. 2023 Dec 28;52(4):1763–1778. doi: 10.1093/nar/gkad1209

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — BG4 binds the telomeric GQ with 1:1 stoichiometry. Representative three-dimensional AFM images and volume histograms for (A) 8 nM BG4, n = 696 particles, (B) 250 mM TELO4, n = 273 particles, (C) 4 nM BG4 reacted with 1 nM TELO4, n = 425 particles, and (D) 4 nM BG4 reacted with 1 nM 4xG2T, n = 173 particles. Gaussian distributions fit to the histograms are shown with mean ± S.D. White scale bar indicates 50 nm, and color scale at top represents height above surface. Each experiment was repeated at least 2–4 times and consisted of multiple depositions per experiment.