Figure 2.

Lack of Tfh cells and absence of IL18 signalling in Tfh lead to a profound reduction of anti-OSE IgG and IgM antibodies, including ‘natural’ IgM antibodies. Data from the same experimental groups as in Figure 1. (A) Total numbers of splenic GC B cells (B220⁺ Gl7^hi CD95^hi; n = 6–11 mice/group). (B–F) Graphs showing total serum subtypes of IgG (B, C) and IgM (D–F) levels. Student’s t-test. *P < 0.05, **P < 0.01, and ***P < 0.001.