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MZB cells are necessary for the formation of IgM natural antibodies. Males and females Ldlr−/−; Cd79aCre/+; RBPflox/flox and Ldlr−/−; Cd79a+/+; RBPflox/flox (WT) were fed a HF/HC diet for 8 weeks (A–F). (A) Schematic diagram of the experimental procedure. (B–F) Graphs showing total serum subtypes of IgG (B–D) and IgM (E–G) levels. Student’s t-test. **P < 0.01.
