Figure 1.

EndMT in health and disease. (A) Schematic representation of EndMT in embryonic development. A subset of ECs lining the AV canal undergo EndMT and mediate endocardial cushion formation. Further endocardial cushion remodelling mediates healthy AV valve formation. Developmental EndMT is also reported in sprouting angiogenesis and in the maturation of pulmonary arteries. (B) In adult life, EndMT has been associated with the onset and progression of numerous cardiovascular diseases and certain malignancies.