Figure 3. Changes in estimated marginal means of Unified Parkinson’s Disease Rating Scale (UPDRS)-II total scores.

(A) and postural instability and gait disturbance (PIGD) subscores (B) after adjustment for age, sex, and disease duration in patients with Parkinson’s disease (PwP) with (n=36) and without (n=66) elevated levels of any one plasma extracellular vesicle synaptic protein (first quartile) at baseline and follow-up. Data are presented as means with 95% confidence intervals. n.s., nonsignificant.