. 2024 Mar 14;12:RP87501. doi: 10.7554/eLife.87501

Table 3. The clinical severity in people with Parkinson’s disease with and without elevated (first quartile) baseline plasma extracellular vesicle (EV) synaptosome-associated protein 25 (SNAP-25), growth-associated protein 43 (GAP-43), and synaptotagmin-1.

p-Value indicates the inter-group comparisons for the changes.

Plasma EV		SNAP-25				GAP-43
		L (n = 74)	H (n = 28)	p	L (n = 74)	H (n = 28)	p	L (n = 74)	H (n = 28)	p
UPDRS- II	Baseline	8.26 ± 5.80	9.04 ± 4.90	<0.001	8.53 ± 5.67	8.32 ± 5.33	<0.001	8.46 ± 5.70	8.50 ± 5.24	<0.001
UPDRS- II	Follow-up	10.38 ± 6.11	13.36 ± 6.72	<0.001	10.65 ± 6.30	12.64 ± 6.53	<0.001	10.57 ± 6.25	12.86 ± 6.58	<0.001
UPDRS-III	Baseline	22.31 ± 9.54	23.89 ± 8.65	0.259	22.22 ± 9.66	24.14 ± 8.25	0.244	21.97 ± 9.37	24.79 ± 8.93	0.145
UPDRS-III	Follow-up	20.01 ± 9.33	24.21 ± 8.87	0.259	19.96 ± 9.25	24.36 ± 8.99	0.244	20.04 ± 9.39	24.14 ± 8.70	0.145
Tremor	Baseline	0.34 ± 0.46	0.46 ± 0.38	0.037	0.34 ± 0.34	0.46 ± 0.37	0.034	0.33 ± 0.34	0.47 ± 0.38	0.014
Tremor	Follow-up	0.27 ± 0.26	0.35 ± 0.32	0.037	0.27 ± 0.26	0.35 ± 0.32	0.034	0.28 ± 0.29	0.32 ± 0.22	0.014
AR	Baseline	1.04 ± 0.46	1.09 ± 0.44	0.300	1.03 ± 0.47	1.11 ± 0.42	0.325	1.03 ± 0.46	1.13 ± 0.45	0.195
AR	Follow-up	0.96 ± 0.46	1.10 ± 0.42	0.300	0.95 ± 0.45	1.12 ± 0.43	0.325	0.96 ± 0.46	1.10 ± 0.42	0.195
PIGD	Baseline	0.76 ± 0.61	0.81 ± 0.44	0.023	0.77 ± 0.60	0.77 ± 0.45	0.046	0.74 ± 0.56	0.86 ± 0.58	0.027
PIGD	Follow-up	0.74 ± 0.59	1.07 ± 0.75	0.023	0.78 ± 0.61	0.98 ± 0.74	0.046	0.73 ± 0.56	1.11 ± 0.80	0.027
MMSE	Baseline	25.32 ± 4.45	25.29 ± 3.29	0.483	25.58 ± 4.16	24.61 ± 4.11	0.470	25.62 ± 3.91	24.50 ± 4.69	0.342
MMSE	Follow-up	24.78 ± 5.93	25.14 ± 4.64	0.483	25.05 ± 5.79	24.43 ± 5.10	0.470	25.23 ± 5.61	23.96 ± 5.50	0.342
MoCA	Baseline	20.68 ± 6.00	21.21 ± 5.00	0.834	21.14 ± 5.77	20.04 ± 5.62	0.899	21.12 ± 5.33	20.07 ± 6.69	0.926
MoCA	Follow-up	20.60 ± 6.85	21.46 ± 5.37	0.834	21.10 ± 6.55	20.18 ± 6.30	0.899	21.19 ± 6.33	19.93 ± 6.80	0.926

L = second to fourth quartile at baseline; H = first quartile at baseline; UPDRS = Unified Parkinson’s Disease Rating Scale; AR = akinetic rigidity; PIGD = postural instability and gait disturbance; MMSE = Mini-Mental Status Examination; MoCA = Montreal Cognitive Assessment.