Fig. 4.

Geometric mean plasma concentration versus time profiles for (A) raloxifene and (B) raloxifene-6-glucuronide after oral administration of raloxifene to mice. A single oral dose of raloxifene (20 mg/kg) administered alone in vehicle (open black circles) or with green tea extract (200 mg/kg) (green squares) and EGCG (12.96 mg/kg) (red triangles) at 0h and then repeated doses of vehicle, green tea extract, and EGCG at 4 and 8h. Symbols and error bars denote geometric means and SDs, respectively, of in the absence and presence of test articles (n=5 per time point).