Table 1.

Small molecule inhibitors of LonP1.

Drug	IC50	Mechanism of Action	Reference
Bortezomib	17 nM	Proteolytic active site inhibitor	[6]
CDDO	13 μM	Allosteric ATPase inhibitor	[34]
CDDO-Me	1.9 μM	Allosteric ATPase inhibitor	[34]
CDDO-Im	2 μM	Allosteric ATPase inhibitor	[34]
Compound 141	0.059 μM	Proteolytic active site inhibitor2	[37]
Coumarinic derivatives 4–8	nd	Proteolytic active site inhibitor	[38]
MG262	122 nM	Proteolytic active site inhibitor	[33]
Obtusilactone A	34.1 μM	Proteolytic active site inhibitor2	[39]
Sesamin	19.9 μM	Proteolytic active site inhibitor2	[39]

¹Boronic acid-based non-peptide inhibitor

²Suggested by computational modelling

nd – Not determined