TABLE I.
Sample composition
| Characteristic | All | Asthma | Nonasthma | P value (asthma vs nonasthma) |
|---|---|---|---|---|
| Sample size | 1035 | 681 | 226 | — |
| Mean age (y) | 9.99 | 10.56 | 9.37 | 1.51 × 10−7 |
| % Female | 46.18 | 43.86 | 52.65 | .025 |
| % Self-reported race and ethnicity | ||||
| Black | 67.25 | 65.20 | 75.22 | .015 |
| Hispanic | 24.93 | 27.50 | 16.81 | |
| White | 1.35 | 1.03 | 1.33 | |
| Other/mixed/unknown | 6.47 | 6.27 | 6.64 | |
| Traits, median (IQR) | ||||
| Allergen sensitization (positive test results) | 3.00 (7) | 4.67 (7.67) | 1.00 (3.33) | 7.6 × 10−21 |
| Total IgE concentration (IU/mL) | 158 (463) | 243 (655) | 70 (123) | 7.67 × 10−21 |
| Blood eosinophil count (cells/mm3) | 200 (300) | 300 (340) | 200 (200) | 3.13 × 10−12 |
| FENO (ppb) | 17.00 (25.54) | 19.50 (29) | 8.00 (11) | 2.77 × 10−16 |
| Blood neutrophil count (cells/mm3) | 2700 (1800) | 2700 (1900) | 2500 (1700) | .01 |
| FEV1 % predicted | 95.50 (20.37) | 93.70 (21.54) | 100.75 (16.61) | 1.20 × 10−8 |
| FEV1/FVC (z score) | −1.06 (1.60) | −1.27 (1.67) | −0.52 (1.20) | 1.49 × 10−17 |
| Bronchodilator response (% change from baseline) | 8.40 (10.82) | 9.80 (11.84) | 5.60 (8.06) | 7.83 × 10−14 |
Results are reported separately by asthma status for the combined APIC and URECA samples. The ages correspond to the year at which total IgE was measured (all other ages listed in Table E1). The medians and IQRs (in parentheses) are listed for all quantitative traits. Missing data were not included in calculations.
FVC, Forced vital capacity; FENO, fractional exhaled nitric oxide; IQR, interquartile range; IU, international units; ppb, parts per billion.