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. 2024 Feb 6;111(3):487–508. doi: 10.1016/j.ajhg.2024.01.007

Figure 4.

Figure 4

Characterization of wild-type and missense ZFX DNA binding by ChIP-seq

(A) Shown is a browser track displaying the genomic binding patterns of WT and variant ZFX proteins in a representative 2.4k-kb region of chromosome 22.

(B) Proportional Venn diagram of overlaps among the top 12,000 called peaks within 2 kb of the transcription start site (TSS) for WT and variant ZFX proteins. The number of peaks common to all ZFXs is indicated.

(C) Shown are the DNA binding profiles of WT and variant ZFX proteins from −2 kb to +2 kb from the TSS.