Figure 8. Vδ2⁺ γδ T cells before immunization and after fourth immunization.

The percentages of CD3⁺ T cells that were Vδ2⁺ before immunization or 2 weeks after the fourth dose of PfSPZ Vaccine (9.0 × 10⁵) or NS in HIV^– (A) and HIV⁺ (B) participants. Results show the percentages of unstimulated CD3⁺ T cells staining positive for Vδ2. Bars indicate median values within each group, and circles indicate individual participant data. In HIV^– vaccinees, the Vδ2⁺ percentages increased after immunization and were higher than the Vδ2⁺ percentages in NS controls, although the difference did not reach statistical significance (P = 0.25, Wilcoxon-Mann-Whitney test adjusted for multiple comparisons). In HIV⁺ vaccinees, there was a small increase in the Vδ2⁺ percentages after immunization, which was not different from that of NS controls (P = 0.88). The percentages of CD3⁺ T cells staining Vδ2⁺ was higher in HIV^– vaccinees compared with HIV⁺ vaccinees before and after immunization (C).