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. 2024 Feb 1;134(6):e171063. doi: 10.1172/JCI171063

Figure 2. CoREST inhibition induces morphological changes in melanoma cells.

Figure 2

(A) Average cell length for MITFhi/AXLlo 451Lu and MITFlo/AXLhi 1205Lu melanoma cells treated with 1 μM corin for 0, 24, and 72 hours (n = 20). Representative images shown. Scale bars: 100 μm. (B) Senescence-associated β-galactosidase staining of 451Lu melanoma cells treated with DMSO or 1 μM corin for 72 hours and quantification. Scale bar: 50 μm. **P < 0.01, ***P < 0.001, and ****P < 0.0001, by 2-tailed, unpaired t test compared with DMSO controls.