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. 2023 May 22;42(3):498–509. doi: 10.1038/s41587-023-01791-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a and b, The editing efficiency of monomeric mitoABEs, including TALE-MutH-TadA8e(V106W), TALE-TadA8e(V106W)-MutH, and TALE-Nt.BspD6I(C)-TadA8e(V106W), TALE-TadA8e(V106W)-Nt.BspD6I(C) at MT-ND1 (a) and MT-ND4 (b). The mean values from n = 3 biologically independent replicates are shown.In a and b, the blue box represents the editing window of the dimeric mitoABEs. c and d, The editing efficiencies of monomeric mitoCBEs, including TALE-MutH-rAPOBEC1-UGI, TALE-rAPOBEC1-UGI-MutH, and TALE-Nt.BspD6I(C)-rAPOBEC1-UGI, TALE-rAPOBEC1-UGI-Nt.BspD6I(C) at MT-ND1 (c) and MT-ND4 (d). The mean values from n = 3 biologically independent replicates are shown. In a-d, the purple rounded rectangle represents MutH, the red rounded rectangle represents Nt.BspD6I(C), the gray rectangle represents TALE, the blue rounded rectangle represents TadA8e(V106W), the green rounded rectangle represents rAPOBEC1 and the brown rounded rectangle represents UGI.