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. 2023 May 22;42(3):498–509. doi: 10.1038/s41587-023-01791-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a-h, The average frequency and mitochondrial genome position of each unique single nucleotide variant (SNV) are shown for MT-ND1-targeting monomeric mitoABE^MutH (TALE-MutH-TadA8e(V106W)) (a), MT-ND4-targeting monomeric mitoABE^MutH (TALE-MutH-TadA8e(V106W)) (b), MT-ND1-targeting monomeric mitoABE^MutH (TALE-TadA8e(V106W)-MutH) (c), MT-ND4-targeting monomeric mitoABE^MutH (TALE-TadA8e(V106W)-MutH) (d), MT-ND1-targeting monomeric mitoABE^Nt.BspD6I(C) (TALE-Nt.BspD6I(C)-TadA8e(V106W)) (e), MT-ND4-targeting monomeric mitoABE^Nt.BspD6I(C) (TALE-Nt.BspD6I(C)-TadA8e(V106W)) (f), MT-ND1-targeting monomeric mitoABE^Nt.BspD6I(C) (TALE-TadA8e(V106W)-Nt.BspD6I(C)) (g), MT-ND4-targeting monomeric mitoABE^Nt.BspD6I(C) (TALE-TadA8e(V106W)-Nt.BspD6I(C)) (h). a-h, all data presented as mean values of n = 3 independent biological replicates. The arrow points to the targeted editing site and the blue dots represent the editing efficiency of adenines in the editing window.