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. 2023 May 22;42(3):498–509. doi: 10.1038/s41587-023-01791-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a and b, Mitochondrial A-to-G editing efficiency of HEK293T cells treated with paired TALE-TadA8e(V106W) at MT-ND1 (a) and MT-ND4 (b). c and d, Mitochondrial A-to-G editing efficiency of HEK293T cells treated with Left-TALE-MutH and Right-TALE-TadA8e(V106W) at MT-ND1 (c) and MT-ND4 (d). e and f, Mitochondrial A-to-G editing efficiency of HEK293T cells treated with Left-TALE-MutH(D70A) and Right-TALE-TadA8e(V106W) at MT-ND1 (e) and MT-ND4 (f). g, Product distributions at the two sites in (c) and (d). In a-f, the blue rounded rectangle represents TadA8e(V106W), the purple rounded rectangle represents MutH, and the gray rectangle represents TALE. h-j, Time-course analysis of editing efficiencies at MT-RNR2 (h), MT-ND1 (i) and MT-ND4 (j). For a-g, data are presented as mean values ± s.d. of n = 3 independent biological replicates. For h-j, all data points from n = 3 biologically independent replicates are shown.