Fig. 1. Cellular immune responses against allogeneic rhesus macaque wt and HIP grafts.

a–e, Immune assays in the group receiving wt^allo first. ELISpot assays with recipient monkey PBMCs drawn at scheduled timepoints (a, mean ± s.d., four monkeys). Killing assays with recipient monkey PBMCs (b), T cells (c), NK cells (d) and macrophages (e). Percent target cell killing is shown on the left y axis (mean ± s.d.), and killing speed is shown on the right y axis (killing t_1/2⁻¹, mean ± s.e.m., four monkeys). f–j, Immune assays in the group receiving HIP^allo first. ELISpot assays with recipient monkey PBMCs (f, mean ± s.d., four monkeys at weeks 0–7, three monkeys at week 8 and two monkeys at weeks 10–16). Killing assays with recipient monkey PBMCs (g), T cells (h), NK cells (i) and macrophages (j). Percent target cell killing is shown on the left y axis (mean ± s.d.), and killing speed is shown on the right y axis (killing t_1/2⁻¹, mean ± s.e.m., four monkeys at weeks 0–7, three monkeys at week 8 and two monkeys at weeks 10–16). All assays run against wt^allo and HIP^allo are shown in blue and red, respectively, at 6 weeks, and, later, all assays were run against both cell types.