Table 2.
Composition and Properties of Inherently Disordered Regions in Human DNAAF Proteins
| DNAAF # | IDR # | Residues (n) | Mol. Wt. (Da) | pI | # Residues (%) | ||||
|---|---|---|---|---|---|---|---|---|---|
| Basic$ | Acidic$ | Polar# | Hydrophobic* | ||||||
| Total | Bulky | ||||||||
| DNAAF1 | 1 | 1–88 (88) | 9,217 | 4.71 | 8 (9.1) | 18 (20.5) | 22 (25.0) | 37 (42.0) | 7 (7.9) |
| 2 | 391–619 (229) | 24,294 | 3.91 | 17 (7.4) | 58 (25.3) | 40 (17.5) | 114 (49.8) | 47 (20.5) | |
| 3 | 640–725 (86) | 8,918 | 4.14 | 5 (5.8) | 11 (12.8) | 26 (30.2) | 44 (51.2) | 15 (17.4) | |
| DNAAF2 | 1 | 348–524 (177) | 17,107 | 4.63 | 15 (8.4) | 26 (14.7) | 40 (22.6) | 96 (54.2) | 17 (9.6) |
| 2 | 670–804 (135) | 15,098 | 4.42 | 11 (8.1) | 27 (20.0) | 54 (40.0) | 43 (31.8) | 30 (22.2) | |
| DNAAF3 | 1 | 462–541 (80) | 8,020 | 3.88 | 1 (1.2) | 9 (11.3) | 23 (28.7) | 45 (56.2) | 16 (20.0) |
| DNAAF4 | 1 | 199–254 (56) | 6,226 | 10.90 | 11 (17.8) | 5 (8.9) | 16 (28.6) | 25 (44.6) | 14 (25.0) |
| DNAAF6 | 1 | 1–109 (109) | 12,160 | 3.55 | 4 (3.7) | 30 (28.5) | 29 (26.6) | 46 (42.2) | 23 (21.1) |
| DNAAF8 | 1 | 1–21 (21) | 2,123 | 5.59 | 1 (4.8) | 1 (4.8) | 6 (28.6) | 13 (61.9) | 2 (9.5) |
| 2 | 34–187 (154) | 16,534 | 4.08 | 11 (7.1) | 32 (20.8) | 34 (22.1) | 71 (46.1) | 31 (20.1) | |
| 3 | 214–260 (41) | 4,127 | 5.59 | 4 (9.7) | 5 (12.2) | 7 (17.1) | 23 (56.1) | 6 (14.6) | |
| 4 | 282–306 (25) | 2,863 | 9.52 | 3 (12.0) | 2 (8.0) | 7 (28.0) | 13 (52.0) | 5 (20.0) | |
| 5 | 329–430 (102) | 10,743 | 4.45 | 9 (8.8) | 19 (18.6) | 32 (31.4) | 42 (41.1) | 12 (11.7) | |
| 6 | 447–520 (74) | 7,690 | 10.39 | 12 (16.2) | 7 (9.4) | 13 (17.5) | 42 (56.7) | 8 (10.8) | |
| DNAAF11 | 1 | 359–466 (108) | 12,217 | 9.17 | 19 (17.6) | 16 (14.8) | 33 (30.5) | 40 (37.0) | 19 (17.6) |
| DNAAF12 | 1 | 1–55 (55) | 6,295 | 9.29 | 9 (16.3) | 7 (12.7) | 16 (29.1) | 23 (41.8) | 12 (21.8) |
| 2 | 259–333 (75) | 7,897 | 4.84 | 6 (8.0) | 9 (12.0) | 18 (24.0) | 42 (56.0) | 18 (24.0) | |
| 3 | 393–542 (150) | 15,850 | 10.98 | 19 (12.6) | 12 (8.0) | 37 (24.7) | 82 (54.7) | 26 (17.3) | |
| DNAAF13 | 1 | 119–165 (47) | 5,497 | 9.47 | 11 (23.4) | 7 (14.9) | 10 (21.2) | 19 (40.4) | 9 (19.1) |
| 2 | 335–445 (111) | 11,118 | 9.77 | 20 (18.0) | 14 (12.6) | 17 (15.3) | 58 (52.2) | 6 (5.4) | |
| 3 | 742–805 (64) | 7,019 | 6.52 | 13 (20.3) | 13 (20.3) | 12 (18.7) | 26 (40.6) | 8 (12.5) | |
| DNAAF14 | 1 | 180–209 (30) | 3,372 | 6.77 | 5 (16.6) | 5 (16.6) | 6 (20.0) | 14 (46.7) | 4 (13.3) |
| DNAAF15 | 1 | 184–234 (51) | 5,612 | 5.01 | 4 (7.8) | 6 (11.7) | 16 (31.4) | 25 (49.0) | 14 (27.4) |
$
Charged residues include Arg and Lys (basic) and Asp and Glu (acidic).
#
Polar residues include Asn, Cys, Gln, His, Ser and Thr.
*
Total hydrophobic residues include Ala, Gly, Ile, Leu, Met, Phe, Pro, Trp, Tyr, and Val. Bulky hydrophobic residues comprise Ile, Leu, Phe, Trp, Tyr, and Val.