Table 2.

Association with incident and prevalent diabetes in replication cohorts (FHS and WHI). *Sex adjustment was not performed in WHI (given study sample was women only), and race adjustment was not performed in FHS.

Prevalent diabetes
		Framingham Heart Study		Women’s Health Initiative
Proteomic score	Adjustments*	Odds Ratio	P	Odds Ratio	P
Pro-inflammatory proteotype score	Age + Sex + Race	1.38 (1.10-1.72)	0.005	1.24 (1.08-1.43)	0.003
	Age + Sex + Race + BMI	1.07 (0.81-1.41)	0.64	1.02 (0.84-1.23)	0.87
Muscularity proteotype score	Age + Sex + Race	1.33 (0.98-1.79)	0.06	0.90 (0.79-1.03)	0.12
	Age + Sex + Race + BMI	1.34 (0.99-1.83)	0.06	0.91 (0.80-1.05)	0.2
Diabetes (Cox) score	Age + Sex + Race	1.87 (1.49-2.36)	<0.0001	1.27 (1.10-1.46)	0.0008
	Age + Sex + Race + BMI	1.70 (1.32-2.18)	<0.0001	1.14 (0.97-1.34)	0.11
Incident diabetes
		Framingham Heart Study		Women’s Health Initiative
Proteomic score	Adjustments*	Odds Ratio	P	Hazard Ratio	P
Pro-inflammatory proteotype score	Age + Sex + Race	1.98 (1.28-3.06)	0.002	1.21 (1.01-1.45)	0.04
	Age + Sex + Race + BMI + Fasting glucose	1.39 (0.77-2.51)	0.27	1.04 (0.81-1.34)	0.75
Muscularity proteotype score	Age + Sex + Race	1.38 (0.80-2.37)	0.25	1.06 (0.88-1.27)	0.56
	Age + Sex + Race + BMI + Fasting glucose	1.37 (0.77-2.46)	0.29	1.00 (0.82-1.20)	0.97
Diabetes (Cox) score	Age + Sex + Race	1.91 (1.28-2.85)	0.002	1.26 (1.05-1.50)	0.01
	Age + Sex + Race + BMI + Fasting glucose	1.24 (0.77-2.01)	0.37	1.06 (0.86-1.32)	0.57