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. 2023 Dec 8;109(4):e1345–e1358. doi: 10.1210/clinem/dgad708

Table 7.

Spearman correlations in 24-hour urine samples in females

Metabolite HbA1c BMI BMI percent BMI-z score BF%
BCAAs mmol/mol Cr, 24 h .456, P = .0013 .09, P = .4610 .083, P = .4985 .078, P = .5259 .049, P = .6918
BCKAs mmol/mol Cr, 24 h .468, P = .0005 .105, P = .3757 .086, P = .4772 .085, P = .4867 .124, P = .3104
KIV mmol/mol Cr, 24 h .544, P < .0001 .213, P = .0704 .188, P = .1189 .187, P = .1218 .2, P = .1002
KMV mmol/mol Cr, 24 h .438, P = .0013 .087, P = .4636 .07, P = .5634 .068, P = .5749 .108, P = .3771
KIC mmol/mol Cr, 24 h .52, P < .0001 .111, P = .3482 .082, P = .5018 .079, P = .5135 .127, P = .2995
Tryptophan mmol/mol Cr, 24 h .418, P = .0023 .077, P = .5184 .108, P = .3737 .105, P = .3876 .035, P = .7737
Kynurenine mmol/mol Cr, 24 h .389, P = .0048 .217, P = .0647 .229, P = .0565 .226, P = .0605 .155, P = .2048
Kynurenic acid mmol/mol Cr, 24 h −.26, P = .0650 −.057, P = .6328 −.074, P = .5450 −.078, P = .5236 −.086, P = .4817
5-HIAA mg/g Cr, 24 h .168, P = .2433 −.24, P = .0426 −.241, P = .0449 −.242, P = .0437 −.289, P = .0162
Serotonin nmol/mmol Cr, 24 h .139, P = .3518 −.044, P = .7187 −.006, P = .9605 −.007, P = .9541 −.043, P = .7311
Kynurenine/tryptophan, 24 h .166, P = .2453 .248, P = .0344 .236, P = .0497 .234, P = .0509 .193, P = .1117
5-HIAA/tryptophan, 24 h −.336, P = .0172 −.29, P = .0134 −.302, P = .0110 −.301, P = .0114 −.264, P = .0281
5-HIAA/kynurenine, 24 h −.363, P = .0096 −.33, P = .0047 −.345, P = .0034 −.344, P = .0036 −.293, P = .0145
Kynurenine/serotonin, 24 h .498, P = .0004 .253, P = .0362 .242, P = .0449 .239, P = .0481 .213, P = .0828
Serotonin/tryptophan, 24 h −.413, P = .0039 −.189, P = .1199 −.16, P = .1881 −.156, P = .1995 −.171, P = .1670

Abbreviations: BCAA, branched-chain amino acid; BCKA, branched-chain ketoacid; BF%, percent body fat; BMI, body mass index; Cr, creatinine; HbA1c, hemoglobin A1c; KIC, α-keto-isocaproate; KIV, α-keto-valerate; KMV, α-keto-β-methylvalerate.