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. 2024 Mar 1;11:1357947. doi: 10.3389/fvets.2024.1357947

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Copyright © 2024 Elmahallawy, Ali, Raya-Álvarez, Fehaid, Abd El-Razik, El Fadaly, El-Khadragy, Sayed, Soror, Alhegaili, Saleh, Alkhaldi, Madboli, Agil and Barakat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Photomicrograph of uterine tissue sections from mice of experimental groups. (A,B) Uterine tissue sections from infected animals treated with wheat germ oil showing (A) normal endometrial epithelium (arrow)., focal mononuclear inflammatory cellular infiltration in endometrium around endometrial glands (arrowheads). A atrophy and degeneration of endometrial glands with peri-glandular edema (zigzag arrows), normal myometrium (M), and normal perimetrium structure (P). (B) Uterine tissue sections from infected animals treated with a combination of propolis + wheat germ oil (G5): marked improvement in the uterine cellular structure, normal endometrial epithelium (arrowhead), normal endometrial gland (zigzag arrow), and mild inflammatory cellular infiltration (thin arrow), and normal blood vessels (red arrowhead). H&E stain, the bar size was indicated under pictures. (C) Histomorphometry graph showing quantitative and semiquantitative measurements of total lesion scores recorded in Uterine tissue sections among the experimental groups. Significant differences vs. the control group are marked by different asterisks through one-way ANOVA with Tukey’s post-hoc test: *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.