Table 4.
Relationship between probiotic and cognitive function in patients.
| Study | Microorganisms | Intervention targets | Impact |
|---|---|---|---|
| Asaoka et al. (2022) | B. breve MCC1274 | MCI patients | The probiotic treatments showed a significant improvement in the MMSE, ADAS-cog scores. Brain atrophy progression had been suppressed. |
| Akbari et al. (2016) | Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum and Lactobacillus fermentum | AD patient | The probiotic treated patients showed a significant improvement in the MMSE score. |
| Tamtaji et al. (2019) | Selenium, Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium longum |
AD patient | The probiotic and selenium treated patients showed a significant improvement in the mini-mental state examination score and cognitive function. |
| Kobayashi et al. (2019) | B. breve MCC1274 | AD patient | The probiotic treated patients showed a significant improvement in the MMSE score and cognitive function. |
| Hwang et al. (2019) | Lactobacillus plantarum | MCI patient |
Increased serum BDNF levels and improved cognitive function after administering DW2009. |
| Kim et al. (2021) | Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI | Older Adults | The probiotic increased serum BDNF levels and improved cognitive function. |