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. 2024 Mar 1;15:1352311. doi: 10.3389/fphar.2024.1352311

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Copyright © 2024 Dong, Ngaba, An, Adeshina, Warren, Wong and Lynch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TID1S overexpression decreases mature frataxin in human skin fibroblasts. Human skin fibroblasts from healthy individuals were transduced with lentivirus carrying pHAGE-TID1S gene or vector control for 5 days before Western blotting or immunofluorescence. TID1S transduction decreased mature frataxin (A, B) and ATP levels (C) (n = 5). TID1S transduction also caused mitochondria fractionation in fibroblasts (D). Vector control was stained with an anti-GFP antibody and TID1S was stained with an anti-TID1L/S antibody. ∗p < 0.05, ∗∗p < 0.01. Data were shown as mean ± SE.